منابع مشابه
Response: fidelity and flexibility
Michael Shopshire: Programs and counselors are clearly interested in and even excited by motivational interviewing (MI) and other evidence-based practices. They attend trainings and say they implement evidence-based practices, but we don’t know what they’re actually doing in their sessions. They may not really be implementing the practices in the way that the creators intended or in a way that ...
متن کاملFidelity and flexibility in coral symbioses
Understanding whether or not corals have the flexibility to change their complement of symbionts to adapt to changing climate is an important goal in reef ecology studies. While host fidelity to a single clade of symbiont is the dominant pattern in present-day corals, current estimates of flexibility are unreliable, because few studies have measured it rigorously and with adequately sensitive g...
متن کاملFidelity versus flexibility: translating evidence-based research into practice.
BACKGROUND Understanding the process by which research is translated into practice is limited. This study sought to examine how interventions change during implementation. METHODS Data were collected from July 2005 to September 2007. A real-time and cross-case comparison was conducted, examining ten interventions designed to improve health promotion in primary care practices in practice-based...
متن کاملMethylation of yeast ribosomal protein Rpl3 promotes translational elongation fidelity.
Rpl3, a highly conserved ribosomal protein, is methylated at histidine 243 by the Hpm1 methyltransferase in Saccharomyces cerevisiae. Histidine 243 lies close to the peptidyl transferase center in a functionally important region of Rpl3 designated as the basic thumb that coordinates the decoding, peptidyl transfer, and translocation steps of translation elongation. Hpm1 was recently implicated ...
متن کاملH3K36 methylation promotes longevity by enhancing transcriptional fidelity.
Epigenetic mechanisms, including histone post-translational modifications, control longevity in diverse organisms. Relatedly, loss of proper transcriptional regulation on a global scale is an emerging phenomenon of shortened life span, but the specific mechanisms linking these observations remain to be uncovered. Here, we describe a life span screen in Saccharomyces cerevisiae that is designed ...
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ژورنال
عنوان ژورنال: Structure
سال: 2009
ISSN: 0969-2126
DOI: 10.1016/j.str.2009.04.003